Publications Paul Coffer

Key publications (for the complete list click here)

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., Deroos, P., Liu, H., Cross, J.R., Pfeffer, K., Coffer, P.J., Rudensky, A.Y. (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504, 451-455.
See also News & Views: Kugelberg 2013. Nature Reviews Immunology 14, 2-3

van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Gröne A, Sijts AJ, Maurice MM, Kalkhoven E, Prakken BJ, Ovaa H, Pan F, Zaiss DM, Coffer PJ (2013), Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity, Immunity, 39, 259-71.
See also News & Views: Laurence et al, 2013. Immunity39, 201-203.

van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ (2013), Canonical wnt signaling negatively modulates regulatory T cell function, Immunity, 39, 298-310.
See also News & Views: Sandri, 2012. Nature Cell Biology4, 786-788.

Zaiss DM, van Loosdregt J, Gorlani A, Bekker CP, Gröne A, Sibilia M, van Bergen en Henegouwen PM, Roovers RC, Coffer PJ, Sijts AJ (2013), Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor, Immunity, 38, 275-84.

Vervoort SJ, van Boxtel R, Coffer PJ. The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe? (2013), Oncogene, 32, 3397-409.

van der Vos KE, Eliasson P, Proikas-Cezanne T, Vervoort SJ, van Boxtel R, Putker M, van Zutphen IJ, Mauthe M, Zellmer S, Pals C, Verhagen LP, Groot Koerkamp MJ, Braat AK, Dansen TB, Holstege FC, Gebhardt R, Burgering BM, Coffer PJ (2012), Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy, Nat Cell Biol, 14, 829-37.

Buitenhuis M, van der Linden E, Ulfman L, Hofhuis F, Bierings M, Coffer P.J. (2010), Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties, Blood, 116, 2373-2384.

van Loosdregt J, Vercoulen Y, Guichelaar T, van Gent YJ, Beekman, JM, van Beekum O, Brenkman A, Hijnen D, Mutis T, Kalkhoven E, Prakken BJ, Coffer P.J. (2010), Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization, Blood, 115, 965-974.

Beekman JM, Verhagen LP, Geijsen N, Coffer PJ (2009), Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output, Blood, 114, 3917-3927.

Geest CR, Buitenhuis M, Groot-Koerkamp MJ, Holstege FC, Vellenga E, Coffer PJ (2009), Tight control of MEK-ERK activation is essential in regulating proliferation, survival and cytokine production of CD34+ derived neutrophil progenitors, Blood, 114, 3402-3412.

Geest CR, Buitenhuis M, Laarhove AG, Bierings MB, Bruin MCA, Vellenga E, Coffer PJ (2009), p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPa on serine 21, Stem Cells, 27, 2271-2282.

Buitenhuis M, Verhagen LP, van Deutekom HW, Castor A, Verploegen S, Koenderman L, Jacobsen SE, Coffer PJ (2007), Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis, Blood, 111, 112-121.

Buitenhuis B, van Deutekom HWM, Verhagen LP, Castor H, Jacobsen SE, Lammers J-WJ, Koenderman L, Coffer PJ (2005), Differential regulation of granulopoiesis by the basic Helix Loop Helix transcriptional inhibitors Id1 and Id2, Blood, 105, 4272-4281.

Dijkers PF, Birkenkamp KU, Lam EW-F, Thomas SB, Lammers J-WJ, Koenderman L, Coffer PJ (2002), FOXO3 can act as a critical effector of cell death induced by cytokine withdrawal: PKB enhanced cell survival through maintenance of mitochondrial integrity, J Cell Biol, 156, 531-542.

Geijsen N, Uings I, Pals C, Armstrong J, Raaijmakers JAM, McKinnon M, Lammers J-WJ, Koenderman L, Coffer PJ (2001), Cytokine-specific transcriptional regulation through an IL-5Ra-interacting protein, Science, 293, 1136-1138.

Dijkers PF, Medema, RH, Lammers J-WJ, Koenderman L, Coffer PJ (2000), Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the Forkhead transcription factor FOXO3a, Curr Biol, 10, 1201-1204.

Burgering BMT, Coffer PJ (1995), Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction, Nature, 376, 599-602.

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