Curriculum Vitae David Egan

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Biographical sketch

A native of Carrickerry, Co. Limerick, Ireland; David Egan graduated from the Industrial Chemistry program at the University of Limerick in 1991. He received his PhD the from Cornell University in 1997 having worked on the transcriptional regulation of P-glycoprotein drug resistance genes in the laboratory of Dr. Kathleen Scotto at Memorial Sloan-Kettering Cancer Center, New York (USA).

Between 1997 and 2001, he had a post-doctoral fellowship with Dr. Ron Evans at the Salk Institute, La Jolla (USA). It was there that he became interested in the use of automated screening methods for drug discovery. This led to a position in the Leads Discovery Group at OSI Pharmaceuticals, Melville (USA).

In 2003 he took a position at the Netherlands Cancer Institute (NKI) in Amsterdam, The Netherlands, initially with Prof. Titia Sixma and Dr. Anastassis 'Tassos' Perrakis. The first year's work involved the automation of protein crystallization screens for the structural biology groups at the NKI. Subsequent work with Prof. Rene Bernards and Dr. Roderick Beijersbergen was on the establishment of the NKI Robotics & Screening Center.

In 2008 he was appointed as Manager of the newly established Cell Screening Center (CSC) in the Department of Cell Biology at the University Medical Center Utrecht, The Netherlands. The CSC is a facility that gives researchers the opportunity to run automated chemical biology and functional genomics screens. Dr. Egan is specifically interested is in the identification of novel targets and therapeutics for cancer and in the development of innovative technologies for cancer drug discovery.

Professional career

1991-1997. PhD study at the Department of Pharmacology, Memorial Sloan-Kettering Cancer Center, Cornell University Medical College, New York, United States of America (Supervisor: Kathleen W. Scotto)
1997-2001. Postdoctoral fellow at the Salk Institute for Biological Studies, La Jolla, United States of America, with Dr. Ronald M. Evans.
2001-2003. Assay technology scientist at the OSI Pharmaceuticals, Melville, United States of America.
2003-2004. Automation scientist at the Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands, with Prof. Titia Sixma.
2004-2008. Automation scientist at Robotic Screening Center of the Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands.
2008-current. Manager at the Cell Screening Center, Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.

Financial support

2010. STW Open Technology Program (with Prof. J. Klumpermann and Prof. G. Strous)

Research interests

  • High throughput screening
  • High content screening
  • Chemical biology
  • Cancer
  • Bioinformatics for high throughput and high content screening
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