Publications David Egan

Kuiken HJ, Egan DA, Laman H, Bernards R, Beijersbergen RL, Dirac AM (2012), Identification of F-box only protein 7 as a negative regulator of NF-kappaB signaling, J Cell Mol Med, in press.

Verrijn Stuart AA, Schipper HS, Tasdelen I, Egan DA, Prakken BJ, Kalkhoven E, de Jager W (2012), Altered plasma adipokine levels and in vitro adipocyte differentiation in pediatric type 1 diabetes, J Clin Endocrinol Metab, 97, 463-72.

de Raad M, Teunissen EA, Lelieveld D, Egan DA, Mastrobattista E (2011), High-content screening of peptide-based non-viral gene delivery systems, J Control Release, in press.

Paul P, van den Hoorn T, Jongsma ML, Bakker MJ, Hengeveld R, Janssen L, Cresswell P, Egan DA, van Ham M, Ten Brinke A, Ovaa H, Beijersbergen RL, Neefjes J (2011), A genome-wide multidimensional RNAi screen reveals pathways controlling MHC Class II antigen presentation., Cell, 145, 268-83.

Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, Schuurman K, van Tellingen O, Morris AJ, Smyth SS, Moolenaar WH, Ovaa H (2010), Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation., Proc Natl Acad Sci USA, 107, 7257-62.

Albers HM, van Meeteren LA, Egan DA, van Tilburg EW, Moolenaar WH, Ovaa H (2010), Discovery and optimization of boronic acid based inhibitors of autotaxin, J Med Chem,53, 4958-67.

Evers B, Schut E, van der Burg E, Braumuller TM, Egan DA, Holstege H, Edser P, Adams DJ, Wade-Martins R, Bouwman P, Jonkers J (2010), A high throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors, Clin Cancer Res, 16, 99-108.

Hadrup SR, Toebes M, Rodenko B, Bakker AH, Egan DA, Ovaa H, Schumacher TN (2009), High-throughput T-cell epitope discovery through MHC peptide exchange, Methods Mol Biol, 524, 383-405.

van Welsem T, Frederiks F, Verzijlbergen KF, Faber AW, Nelson ZW, Egan DA, Gottschling DE, van Leeuwen F (2008), Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core, Mol Cell Biol, 28, 3861-72.

Huang Q, Gumireddy K, Schrier M, le Sage C, Nagel R, Suresh Nair, Egan DA, Li A, Huang G, Klein-Szanto AJ, Gimotty PA, Katsaros D, Coukos G, Zhang L, Puré E, Agami R (2008), The microRNAs miR-373 and miR-520C promote tumor migration, invasion and metastasis, Nat Cell Biol, 10, 202-10.

Kuijl C, Savage ND, Marsman M, Tuin AW, Janssen L, Egan DA, Ketema M, van den Nieuwendijk R, van den Eeden SJ, GelukA, Poot A, van der Marel G, Beijersbergen RL, Overkleeft H, Ottenhoff TH, Neefjes J (2007), Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1, Nature, 450, 725-730.

le Sage C, Nagel R, Egan DA, Schrier M, Mesman E, Mangiola A, Anile C, Maira G, Mercatelli N, Ciafrè SA, Farace MG, Agami R (2007), Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation, EMBO J, 26, 3699-708.

Newman J, Egan D, T. S. Walter TS, Meged R, Berry I, Ben Jelloul M, Sussman JL, Stuart DI, and Perrakis A (2005), Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy, Acta Cryst, 61: 1426-1431.

Boisclair MD, Egan DA, Huberman K, Infantino R (2004), High throughput screening in industry. In: Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval. 2nd Edition. Humana Press.

Torii S, Egan DA, Evans RA, Reed JC (1998), Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs), EMBO J, 18, 6037-49.

Egan DA, Evans RM (1999), Target acquisition and acute promyelocytic leukemia, J Clin Invest, 103, 1367-8.

Doucas V, Tini M, Egan DA, Evans RM (1999), Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling, Proc Natl Acad Sci USA, 96, 2627-32.

Lin RJ, Egan DA, Evans RM (1999), Molecular genetics of acute promyelocytic leukemia, Trends Genet,15, 179-84.

Scotto KW and Egan DA (1998), Transcriptional regulation of MDR genes, Cytotechnology, 27, 257-269.

Rosenfeld MR, Wong E, Dalmau J, Manley G, Egan D, Posner JB, Sher E, Furneaux HM (1993), Sera from patients with Lambert-Eaton myasthenic syndrome recognize the beta-subunit of Ca2+ channel complexes, Ann N Y Acad Sci, 681, 408-11.

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