Curriculum Vitae Anton Martens

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Biographical sketch

Anton Martens (1952) studied Clinical Chemistry at the BMAS-HLO, Breda, The Netherlands from 1968 to 1971. In 1972 his scientific career started at the Radiobiological Institute (RBI) TNO, Rijswijk, The Netherlands, where he participated in leukemia and stem cell related research. In 1984 he started research that led to his thesis on Normal and leukemic stem cells during minimal residual disease under the guidance of Professor D.W. van Bekkum. In 1988 he obtained his PhD from the University of Leiden, The Netherlands.

In 1993 he moved to the Department of Hematology, Erasmus University Rotterdam, The Netherlands (head Professor B. Löwenberg) were he conducted research on experimental therapy development for the treatment of acute leukemia.

In 1997 he moved to the Department of Hematology, University Medical Center Utrecht were he continued stem cell-oriented research in hemato-oncology, acute leukemia and multiple myeloma. At the UMC Utrecht he implemented bioluminescence imaging (BLI) technology as a tool for the in vivo monitoring of normal and leukemic stem cells, and various other applications in preclinical biomedical research. His research interest shifted towards the development of experimental therapies for multiple myeloma and on the characterization of mesenchymal stem cells in bone development.

In 2007 Anton Martens joined the Department of Immunology of the UMC Utrecht (head Professor Frank Miedema) were he continued his research and combined the two research lines (myeloma and bone forming stem cells) this to establish a novel fully humanized mouse model to study normal hematopoiesis and the pathogenesis of human multiple myeloma in its natural environment. This model has also been exploited to monitor tumor growth and response to chemotherapy and immunotherapy using imaging technology. This research is performed within the context of developing novel strategies for the treatment of leukemia and myeloma.

From 2011 he is continuing this research at the Department of Cell Biology of the UMC Utrecht (head Professor Judith Klumperman).

Professional career

1968. Secundary education: MULO-B (Gilze-Rijen), The Netherlands.
1968 –1971. HLO- Training (Clinical Chemistry) at the BMAS, Breda,The Netherlands.
1971 – 1972. Technician at the laboratory of the Roman Catholic Hospital in Dordrecht, The Netherlands.
1972 - 1988. Research technician involved in various projects in experimental leukemia research RBI-TNO.
1988.  PhD at the State University of Leiden, The Netherlands.
1988 – 1993. Member of the scientific staff of the Radiobiological Institute TNO, Rijswijk, The Netherlands
1993 – 1997. Member of the scientific staff of the Institute of Hematology from the Erasmus University of Rotterdam, The Netherlands.
1997 – 2006. Senior staff member of the Department of Hematology of the UMC Utrecht, The Netherlands.
2006 – 2011. Senior staff member of the Department of Immunology-UMC Utrecht, The Netherlands.
2011 – current. Senior staff member at the Department of Cell Biology-UMC Utrecht, The Netherlands.

Awards and honors

1992. The Bekales Prize for leukemia research, Bekales Foundation, Belgium
2000. Research grant 2000, Bekales Foundation, Belgium
2010. Senior research award, Multiple Myeloma Research Foundation (MMRF), USA

Financial support

1993. Dutch Cancer Society (KWF-NKB) grant (with A. Hagenbeek)
1993. Dutch Cancer Society (KWF-NKB) grant (with A. Hagenbeek)
1994. Dutch Cancer Society (KWF-NKB) grant (with I.P. Touw)
1994. Dutch Cancer Society (KWF-NKB) grant (with A. Hagenbeek)
1994. Dutch Cancer Society (KWF-NKB) grant (with I.P. Touw)
2003. Middle size investment grant Photonimager (with S. Ebeling)
2003. NWO Pilot phase DPTE (with A. Hagenbeek and W Dhert)
2006. Wilhelmina Children's Hospital Foundation (WKZ Fonds) grant (with N. Wulfraat)
2006. Association for Int. Cancer Research (AICR) UK grant (with T. Mutis and H. Lokhorst)
2006. Dutch Program for Tissue Engineering (NWO-DPTE) grant
2008. ZonMW: Translational Adult Stem cell Research with G. Wagemaker and N. Wulffraat)
2008. Biotech-sponsored research project. Genmab BV, The Netherlands
2009. Vanderes Foundation grant
2010. Senior Research grant, MMRF, USA
2011. Dutch Cancer Society
2012. Biotech spondored projects Janssen R&D
2013. Leukemia and Lymphoma Society (with Dr Mitsiades, DFCI
2014. Leukemia and Lymphoma Society (with Dr. R Groen, UMCU and Dr C. Mitsiades, DFCI)

Research interests

hematopoietic niche; hematopoietic- and stromal stem cells;
normal hematopoiesis, multiple myeloma, acute leukemia
cellular immunotherapy; antibody mediated immunotherapy
molecular imaging, humanized animal models

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