Curriculum Vitae Madelon Maurice

Biographical sketch

Madelon Maurice graduated in Medical Biology from the Free University, Amsterdam in 1993. She earned her PhD degree in 1998 at the Department of Rheumatology, Leiden University Medical Center (LUMC) on the subject Studies on T cell function in rheumatoid arthritis. In 1997, she received a EULAR award for her PhD work at the European Workshop for Rheumatology Research.

From 1998 to 2001, she was employed as a postdoctoral fellow at Harvard Medical School, Boston, USA, in the lab of Prof. Hidde Ploegh, supported by a HFSP and a JDF fellowship. The research topic was The molecular requirements of positive selection of CD8+ T cells in the thymus. Her work unexpectedly revealed that MHC class Ib products play a key role in the migration of thymus-derived T cells to distant epithelia early in development.

In 2001 she moved back to The Netherlands to work as a senior post-doc in the laboratory of Professor Hans Clevers, Hubrecht Institute, Utrecht, supported by a Zon-MW fellowship. Here, she initiated two independent research lines: The biological role of the deubiquitinating enzyme USP7 and the mechanisms by which ubiquitin controls Wnt/β-catenin signaling.

From 2006, she became Assistant Professor and from 2012 Associate Professor at the Department of Cell Biology, University Medical Center Utrecht, where she is leading her independent research group. The focus of her work is on the molecular mechanisms by which cells interpret Wnt signals received at their cell surface and how dysregulation of these events by mutations leads to cancer. The innovative nature of her work was awarded by an ERC Starting Grant in 2009. Recent highlights include the identification of the E3 ubiquitin ligase RNF43 as a novel tumour suppressor that inhibits Wnt signaling in intestinal stem cells (Nature, 2012). This work places ubiquitin-mediated downregulation of Frizzled receptors central to the mechanisms of growth restriction of the stem cell zone.

Professional career

1993-1998. PhD study at the t the Department of Rheumatology, Leiden University Medical Center, The Netherlands (Supervisors: Dr. CL Verweij and Prof. FC Breedveld).
1998-2001. Postdoctoral fellow at the Department of Pathology, Harvard Medical School, Boston. United States of America, with Prof. Hidde Ploegh.
2001-2005. Postdoctoral fellow at the Hubrecht Laboratory, Utrecht. The Netherlands with Prof. Hans Clevers.
2006-2011. Assistant Professor at the Department of Cell Biology, University Medical Center Utrecht, The Netherlands.
2012-current. Associate Professor at the Department of Cell Biology, University Medical Center Utrecht, The Netherlands.

Awards and honors

1997. EULAR award from the European Workshop for Rheumatology Research.
1998-2000. Human Frontiers in Science Program (HFSP) postdoctoral fellowship
2000-2002. Juvenile Diabetes Foundation (JDF) postdoctoral fellowship
2002-2005. ZonMW postdoctoral fellowship
2010. Elected associated member of the Bijvoet Center for Biomolecular Research
2013. Member of the Young Academy of Europe

Financial support

2005. NKB/KWF project grant
2006. University Utrecht High Potential grant (with S Rudiger)
2009. ERC starting grant
2012. ERC Proof of Concept grant
2013. FP7 Marie Curie ITN grant “WntsApp” (coordinator role)
2013. NWO ECHO grant

Research interests

Wnt signal transduction
Protein trafficking
Ubiquitination
Missense mutations in cancer
Stem cell biology

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