Publications Ger Strous

Key publications (for the complete list click here)

da Silva Almeida AC, Hocking HG, Boelens R, Strous GJ, van Rossum AG (2013), ßTrCP interacts with the ubiquitin-dependent endocytosis motif of the GH receptor in an unconventional manner. Biochem J. 453, 291-301.

Sedek M, Strous GJ (2013), SUMOylation is a regulator of the translocation of Jak2 between nucleus and cytosol. Biochem J. 453, 231-239.

Hassink G, Slotman J, Oorschot V, Van Der Reijden BA, Monteferrario D, Noordermeer SM, Van Kerkhof P, Klumperman J, Strous GJ (2012), Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport. Biol Open 1, 607-614.

Nespital T, Strous GJ (2012), The Jak/STAT signaling pathway is downregulated at febrile temperatures. PLoS One 7, e49374.

Slotman JA, da Silva Almeida AC, Hassink GC, van de Ven RH, van Kerkhof P, Kuiken HJ, Strous GJ (2012), Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis. J Biol Chem, 287, 15533-15543.

da Silva Almeida AC, Strous GJ, van Rossum AG (2012), ?TrCP controls GH receptor degradation via two different motifs, Mol Endocrinol, 26, 165-77.

Putters J, da Silva Almeida AC, van Kerkhof P, van Rossum AG, Gracanin A, Strous GJ (2011), Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor, PLoS ONE, 6, e14676.

van Kerkhof P, Putters J, Strous GJ (2007) The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor, J Biol Chem, 282, 20475-20483.

van den Eijnden MJ, Strous GJ (2007), Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling, Mol Endocrinol, 21, 2832-2846.

Gent J, van Kerkhof P, Roza M, Bu G, Strous GJ (2002), Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis, Proc Natl Acad Sci USA, 99, 9858-9863.

Govers R, ten Broeke T, van Kerkhof P, Schwartz AL, Strous GJ (1999), Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor, EMBO J, 18, 28-36.

Strous GJ, van Kerkhof P, Govers R, Ciechanover A, Schwartz AL (1996), The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor, EMBO J, 15, 3806-3812.

Klomp LW, Van Rens L, Strous GJ (1995), Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains, Biochem J, 308, 831-838.

Stoorvogel W, Strous GJ, Geuze HJ, Oorschot V, Schwartz AL (1991), Late endosomes derive from early endosomes by maturation, Cell, 65, 417-427.

Rijnboutt S, Aerts HM, Geuze HJ, Tager JM, Strous GJ (1991), Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells, J Biol Chem, 266, 4862-4868.

van den Bosch RA, du Maine AP, Geuze HJ, van der Ende A, Strous GJ (1988), Recycling of 5'-nucleotidase in a rat hepatoma cell line, EMBO J, 7, 3345-3351.

Strous GJ, Van Kerkhof P, Brok R, Roth J, Brada D (1987), Glucosidase II, a protein of the endoplasmic reticulum with high mannose oligosaccharide chains and a rapid turnover, J Biol Chem, 262, 3620-3625.
Stoorvogel W, Geuze HJ, Strous GJ (1987), Sorting of endocytosed transferrin and asialoglycoprotein occurs immediately after internalization in HepG2 cells, J Cell Biol, 104, 1261-1268.

Strous GJ, Van Kerkhof P, Willemsen R, Geuze HJ, Berger EG (1983), Transport and topology of galactosyltransferase in endomembranes of HeLa cells, J Cell Biol, 97, 723-727.
Lodish HF, Kong N, Snider M, Strous GJ (1983), Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic rates, Nature, 304, 80-83.

Geuze HJ, Slot JW, Strous GJ, Lodish HF, Schwartz AL (1983), Intracellular site of asialoglycoprotein receptor-ligand uncoupling: double-label immunoelectron microscopy during receptor-mediated endocytosis, Cell, 32, 277-287.