Curriculum Vitae Peter van der Sluijs

Biographical sketch

Peter van der Sluijs studied Pharmacy and Chemistry at the University of Groningen. He obtained a PhD from the same university in 1987 for investigations on hepatic drug targeting in the group of Prof. Dr. Dick Meijer at the Department of Pharmacology and Therapeutics. Afterwards he was a visitor in the lab of Prof. Erik de Clercq at the Rega Institute in Leuven, to develop anti HIV drug-carrier conjugates for targeting CD4-positive T-lymphocytes.

In 1987 he moved to Heidelberg for postdoctoral research in the Cell Biology Program at the European Molecular Biology Laboratory. He joined the lab of Thomas Kreis to study mechanisms of microtubule dependent organelle positioning and motility. With Claude Anthony and Mark Bennett he developed quantitative microtubule-organelle binding assays that were subsequently used for identification of relevant proteins.

In 1989 he went to New Haven for postdoctoral work in the group of Ira Mellman at the Department of Cell Biology, Yale University School of Medicine. Here he became interested in mechanisms regulating transport through endosomes. In collaboration with Bruno Goud and Armand Tavitian he discovered rab4 on early endosomes and demonstrated its function in endosomal recycling.

In 1993 he joined the Department of Cell Biology of the University Medical Center Utrecht as a KNAW Investigator. Here he became interested in (signaling) mechanisms regulating intracellular communication in health and disease. During this period new principles were defined for traffic pathways from the endosomal system and secretory lysosomes, the regulation of water transport in kidney, cell migration, and function of TSC1 and TSC2 gene products.

Professional career

1984 - 1987. PhD study at the Department of Pharmacology and Therapeutics of the University of Groningen, The Netherlands (supervisor: Prof. Dr. D.K.F. Meijer)
1987. Visiting scientist at Department of Virology of the REGA Institute of Medicine, University of Leuven, Leuven, Belgium, with Prof. Dr. E. de Clercq
1987 - 1989. Postdoctoral fellow at Cell Biology Program of the European Molecular Biology Laboratory, Heidelberg, Germany, with Dr. T.E. Kreis
1989 - 1993. Postdoctoral fellow at the Department of Cell Biology of the Yale University Medical School, New Haven, United States of America, with Ira Mellman
1991. Visiting scientist at European Molecular Biology Laboratory, Heidelberg, Heidelberg , Germany, with Dr. J. Gruenberg
1993 - 1998. KNAW investigator at Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.
1998 - current. Associate Professor at Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.

Fellowships and awards

1987. Vlaamse Gemeenschap Fellowship (Belgium)
1987 - 1989. Alexander von Humboldt Stiftung Fellowship (Germany)
1989 - 1991. EMBO long-term Fellowship
1989 - 1992. Leukemia Society of America Fellowship (USA)
1991. Leukemia Society of America Travel Fellowship (USA)
1992 - 1994. Donaghue Medical Research Foundation Fellowship (USA)

Financial support

1993. KNAW Academy Investigator award
1994. Stichting de Drie Lichten Supplies grant
1995. Dekker-Bouwman Stichting Supplies grant
1995. DFN Project grant
1995. KWF/RUU Project grant
1996. NWO/ALW Project grant (with Dr. J. Klumperman)
1996. NWO/SON-ALW Project grant (with Prof. Dr. G. van Meer)
1996. NWO/MW Project grant
1997. NWO/MW Investment grant
1998. NWO/ALW Project grant
1998. NWO/MW Program grant (with Prof. Dr. C.A. van Os, Dr. P. Deen)
2001. NWO/MW Network grant
2001. NWO/MW Program grant (with Dr. D. Halley)
2002. KWF/UU Project grant
2002. NWO/CW TOP Program grant (with Prof. Dr. A. Heck and Prof. Dr. I. Braakman)
2003. Subproject for the Netherlands Proteomics Center Initiative
2003. KWF/UU Project grant (2003-2958)
2008. NWO/CW ECHO Project grant (700.56.003)

Research interests

degranulation in cytotoxic lymphocytes
membrane traffic through endosomal-lysosomal system
recycling endosomes in cell surface remodeling
rab GTPases and effector networks

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