Publications Madelon Maurice

Key publications (for the complete list click here)

Minde DP, Radli M, Forneris F, Maurice MM*, Rüdiger SG* (2013) Large Extent of Disorder in Adenomatous Polyposis Coli Offers a Strategy to Guard Wnt Signalling against Point Mutations, PLoS One. 8(10):e77257 (*co-corresponding)

van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Gröne A, Sijts AJ, Maurice MM, Kalkhoven E, Prakken BJ, Ovaa H, Pan F, Zaiss DM, Coffer PJ (2013) Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity, Immunity 39(2):259-71

van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ (2013) Canonical Wnt signaling negatively modulates regulatory T cell function, Immunity 39(2):298-310

Xue B, Romero PR, Noutsou M, Maurice MM, Rüdiger SG, William AM Jr, Mizianty MJ, Kurgan L, Uversky VN, Dunker AK (2013) Stochastic machines as a colocalization mechanism for scaffold protein function. FEBS Lett. 587(11):1587-91

Minde DP, Maurice MM*, Rüdiger SGD* (2012), Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp, PLOS One, 7:e46147 (*co-corresponding)

Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJR, Maurice MM*, Clevers H* (2012),Tumour suppressor RNF43 is a stem cell E3 ligase that induces endocytosis of Wnt receptors, Nature, 488, 665-9. (*co-corresponding)

Li VSW, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJR, Maurice MM, Mahmoudi T, and Clevers H (2012), Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex, Cell, 149:1245-1256.

Tauriello DVF*, Jordens I*, Kirchner K, Slootstra J, Kruitwagen T, Bouwman BAM, Rudiger SGD, Schwamborn K, Schambony A, Maurice MM (2012), Dvl employs its DEP domain and C-terminus to bind a discontinuous motif in the Fz receptor and initiate Wnt/ β-catenin signalling. Proc Natl Acad Sci USA, 149, 1245-56. (*equal contribution)

Nethe M, de Kreuk BJ, Tauriello DVF, Anthony EC, Snoek B, Stumpel T, Salinas PC, Maurice MM, Geerts D, Deelder AM, Hensbergen PJ, Hordijk PL (2012), Rac1 acts in conjunction with Nedd4 and Dishevelled-1 to promote maturation of cell-cell contacts. J Cell Sci, 125, 3430-42.

Minde, DP, Anvarian Z, Rudiger SGD, Maurice MM (2011), Messing up disorder: How do missense mutations in the tumor suppressor APC lead to cancer? Mol Cancer, 10:101.

Noutsou M, Duarte AMS, Anvarian Z, Didenko T, Minde DP, Kuper I, de Ridder I, Oikonomou C, Friedler A, Boelens R, Rüdiger SGD, Maurice MM (2011). Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded, J Mol Biol, 405, 773-786.

Tauriello DVF, Maurice MM (2010), The various roles of ubiquitin in Wnt pathway regulation, Cell Cycle, 9, 3700-3709.

Tauriello DVF, Haegebarth A, Kuper I, Canninga-van Dijk M, Edelmann MJ, Henraat M, Kessler, BM, Clevers H, Maurice MM (2010), Loss of the tumor suppressor CYLD enhances Wnt/b-catenin signaling through K63-linked ubiquitination of Dvl, Mol Cell, 37, 607-619.

Ten Klooster JP, Janssen M, Oorschot V, Di Giacomo V, Maurice MM, Clevers H (2009), Lkb1 regulates brush border formation of intestinal epithelial cells through Mst4 and Ezrin, Dev Cell, 16, 551-62.

Franch-Marro X, Wendler F, Griffith J, Maurice MM, Vincent JP (2008), In vivo role of the palmitate moiety at Cysteine 93 of Wingless, J Cell Sci, 121, 1587-92.

Franch-Marro X, Wendler F, Guidato S, Griffith J, Baena-Lopez A, Itasaki N, Maurice MM, Vincent JP (2008) Wingless Wingless secretion requires endosome-to-Golgi retrieval of Wntless-Evi-Sprinter by the retromer complex, Nat Cell Biol, 10, 170-77.

Kessler BM, Fortunati L, Coffer P, Melis M, Clevers HC, Maurice MM (2007), Proteome changes induced by knock-down of the deubiquitinating enzyme USP7, J Proteome Res, 6, 4163-72.

Becker K, Marchenko ND, Maurice M, Moll UM (2007), Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma, Cell Death Diff, 14, 1350-60.

Van der Horst, AA, de Vries-Smits AMM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM (2006), FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP, Nat Cell Biol, 8, 1064-73.

Maurice MM*, Meulmeester E*, Teunisse AFAS, Ovaa H, Boutell C, Abraham T, Dirks RW, Jochemsen AG (2005), Loss of HAUSP (USP7)-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2, Mol Cell, 18, 565-576. *equal contribution

Mintern JD, Maurice MM, Ploegh HL, Schott E (2004), Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex, J Immunol, 172, 699-708.